Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep883 | Growth hormone IGF axis - basic | ECE2017

A surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH)

Farhat Khalil , Bodart Gwennaelle , Renard Chantal , Desmet Christophe , Moutschen Michel , Baron Frederic , Beguin Yves , Salvatori Roberto , Matens Henri , Geenen Vincent

In the framework of close interactions between the immune and neuroendocrine systems, Growth Hormone (GH) has been proposed to exert significant effects on the immune system, but there is not yet a consensus about GH immunomodulatory properties. These studies investigated the immune and anti-infectious response of dwarf Ghrh−/− mice presenting a severe deficiency of the GHRH/GH/IGF-1 axis. In basal conditions, thymic parameters and T-cell respon...